Michael B. Hoffman - 28 Oct 2025 Form 4 Insider Report for Annovis Bio, Inc. (ANVS)

Role: Director
Signature: /s/ Maria Maccecchini Attorney-in-Fact
Issuer symbol: ANVS
Transactions as of: 28 Oct 2025
Net transactions value: +$2,000,000
Form type: 4
Filing time: 12 Nov 2025, 09:18:23 UTC
Previous filing: 03 Sep 2025
Next filing: 18 Nov 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Hoffman Michael B	Director	C/O ANNOVIS BIO, INC., 101 LINDENWOOD DR, SUITE 225, MALVERN	/s/ Maria Maccecchini Attorney-in-Fact	12 Nov 2025	0001290208

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ANVS	Common Stock	Purchase	$2,000,000	+975,610	+66%	$2.05	2,455,539	28 Oct 2025	Direct
holding	ANVS	Common Stock						223,357	28 Oct 2025	The 2018 Jane and Michael Hoffman Descendants Trust	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The shares are held in a family trust formed by the reporting person and the reporting person has voting and investment power over such shares.