Jeremy M. Sclar 2012 Irrevocable Family Trust - 25 Jul 2025 Form 4 Insider Report for ProMIS Neurosciences Inc. (PMN)

Role: 10%+ Owner
Signature: Jeremy M. Sclar 2012 Irrevocable Family Trust By: /s/ Richard A. Marks, Trustee
Issuer symbol: PMN
Transactions as of: 25 Jul 2025
Net transactions value: $0
Form type: 4
Filing time: 30 Sep 2025, 16:17:04 UTC
Previous filing: 30 Sep 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Jeremy M. Sclar 2012 Irrevocable Family Trust	10%+ Owner	33 BOYLSTON STREET, SUITE 3000, CHESTNUT HILL	Jeremy M. Sclar 2012 Irrevocable Family Trust By: /s/ Richard A. Marks, Trustee	30 Sep 2025	0002089163

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	PMN	Common Shares, no par value	Exercise of in-the-money or at-the-money derivative security		+697,674	+43%		2,315,111	25 Jul 2025	Direct	F1
transaction	PMN	Common Shares, no par value	Exercise of in-the-money or at-the-money derivative security		+697,674	+30%		3,012,785	25 Jul 2025	Direct	F2
transaction	PMN	Common Shares, no par value	Exercise of in-the-money or at-the-money derivative security		+697,674	+23%		3,710,459	25 Jul 2025	Direct	F3

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	PMN	Tranche A Common Share Purchase Warrants	Exercise of in-the-money or at-the-money derivative security	$0	-697,674	-100%	$0.000000	0	25 Jul 2025	Common Shares	697,674		Direct	F1
transaction	PMN	Tranche B Common Share Purchase Warrants	Exercise of in-the-money or at-the-money derivative security	$0	-697,674	-100%	$0.000000	0	25 Jul 2025	Common Shares	697,674		Direct	F2
transaction	PMN	Tranche C Common Share Purchase Warrants	Exercise of in-the-money or at-the-money derivative security	$0	-697,674	-100%	$0.000000	0	25 Jul 2025	Common Shares	697,674		Direct	F3
transaction	PMN	Warrant to Purchase Common Shares	Purchase		+3,139,533			3,139,533	29 Jul 2025	Common Shares	3,139,533		Direct	F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	On July 25, 2025, the Jeremy M. Sclar 2012 Irrevocable Family Trust (the "JS Trust") exercised 697,674 Tranche A purchase warrants, each exercisable to purchase one Common Share. These warrants were exercisable at an exercise price of $2.02 per warrant share; however, following an offer by the JS Trust and an acceptance by the Issuer, were exercised in full at an exercise price of $0.83518 per share.
F2	On July 25, 2025, the JS Trust exercised 697,674 Tranche B purchase warrants, each exercisable to purchase one Common Share. These warrants were exercisable at an exercise price of $2.02 per warrant share; however, following an offer by the JS Trust and an acceptance by the Issuer, were exercised in full at an exercise price of $0.83518 per share.
F3	On July 25, 2025, the JS Trust exercised 697,674 Tranche C purchase warrants, each exercisable to purchase one Common Share. These warrants were exercisable at an exercise price of $2.50 per warrant share; however, following an offer by the JS Trust and an acceptance by the Issuer, were exercised in full at an exercise price of $0.83518 per share.
F4	On July 29, 2025, the JS Trust acquired a warrant to purchase 3,139,533 Common Shares at an exercise price of $1.25 per share. The purchase price for the warrant was $0.1875 per Common Share underlying the warrant. The warrant is currently exercisable and expires five years after the date of issuance.