Melisa Denis - 03 Sep 2025 Form 4 Insider Report for SmartKem, Inc. (SMTK)

Role: Director
Signature: /s/ Barbra Keck, attorney-in-fact for Melisa A. Denis
Issuer symbol: SMTK
Transactions as of: 03 Sep 2025
Net transactions value: $0
Form type: 4
Filing time: 05 Sep 2025, 18:04:12 UTC
Previous filing: 10 Jun 2025
Next filing: 08 Dec 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Denis Melisa	Director	C/O SMARTKEM, MANCHESTER TECHNOLOGY CTR, HEXAGON TOWER DELAUNAYS ROAD, BLACKLEY, MANCHESTER, UNITED KINGDOM	/s/ Barbra Keck, attorney-in-fact for Melisa A. Denis	05 Sep 2025	0001834132

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SMTK	Stock Option (right to buy)	Award	$0	+22,466		$0.000000	22,466	03 Sep 2025	Common Stock	22,466	$1.16	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The option vests as follows: 25% on the date of grant with the remaining shares to vest in equal monthly installments over a period of 36 months commencing on September 3, 2025 and on the 3rd date of each month thereafter.