Pamela J. Cramer - 09 Jul 2025 Form 4 Insider Report for RHYTHM PHARMACEUTICALS, INC. (RYTM)

Role
Chief Human Resources Officer
Signature
/s/ Stephen Vander Stoep, attorney-in-fact for Pamela J. Cramer
Issuer symbol
RYTM
Transactions as of
09 Jul 2025
Net transactions value
-$991,909
Form type
4
Filing time
11 Jul 2025, 16:30:11 UTC
Previous filing
10 Jun 2025
Next filing
29 Jul 2025
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Cramer Pamela J. Chief Human Resources Officer C/O RHYTHM PHARMACEUTICALS, INC., 222 BERKELEY STREET, 12TH FLOOR, BOSTON /s/ Stephen Vander Stoep, attorney-in-fact for Pamela J. Cramer 11 Jul 2025 0001873517

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction RYTM Common Stock Options Exercise $71,720 +10,547 +55% $6.80 29,756 09 Jul 2025 Direct
transaction RYTM Common Stock Options Exercise $137,434 +5,025 +17% $27.35 34,781 09 Jul 2025 Direct
transaction RYTM Common Stock Sale $319,217 -4,225 -12% $75.55 30,556 09 Jul 2025 Direct F1, F2
transaction RYTM Common Stock Sale $600,565 -7,831 -26% $76.69 22,725 09 Jul 2025 Direct F1, F3
transaction RYTM Common Stock Sale $281,280 -3,516 -15% $80.00 19,209 09 Jul 2025 Direct F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction RYTM Stock Options (Right to Buy) Options Exercise $0 -10,547 -37% $0.000000 17,581 09 Jul 2025 Common Stock 10,547 $6.80 Direct F4
transaction RYTM Stock Options (Right to Buy) Options Exercise $0 -5,025 -25% $0.000000 15,075 09 Jul 2025 Common Stock 5,025 $27.35 Direct F5
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.
F2 The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $75.08 to $75.98 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
F3 The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $76.17 to $76.75 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
F4 The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.
F5 The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.