Redmile Group, LLC - Oct 7, 2021 Form 4 Insider Report for Science 37 Holdings, Inc. (SNCE)

Role: Director, 10%+ Owner
Signature: By: /s/ Jeremy Green, Managing Member of Redmile Group, LLC
Stock symbol: SNCE
Transactions as of: Oct 7, 2021
Transactions value $: $0
Form type: 4
Date filed: 10/12/2021, 09:00 PM
Previous filing: Oct 8, 2021
Next filing: Apr 21, 2023

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SNCE	Stock Option (Right to Buy)	Award	$0	+41.4K		$0.00	41.4K	Oct 7, 2021	Common Stock	41.4K	$10.05	See Footnotes	F1, F2, F3, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The equity award was granted to Robert Faulkner, a managing director of Redmile Group, LLC ("Redmile"), in connection with his service as a member of the board of directors of the Issuer. Pursuant to the policies of Redmile, Mr. Faulkner holds this equity award as a nominee on behalf, and for the sole benefit, of Redmile and has assigned all economic, pecuniary and voting rights in respect of the equity award to Redmile. Mr. Faulkner disclaims beneficial ownership of the equity award, and the filing of this Form 4 shall not be deemed an admission that Mr. Faulkner is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.
F2	The equity award may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. Redmile and Mr. Green disclaim beneficial ownership of the equity award except to the extent of their pecuniary interest therein, and this Form 4 shall not be deemed an admission that Redmile or Mr. Green is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.
F3	Mr. Faulkner, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.
F4	The shares subject to the stock option will vest in full upon the earlier of (i) October 7, 2022 or (ii) the date of the Issuer's 2022 Annual Meeting of Stockholders, subject to Robert Faulkner's continued service on the board of directors of the Issuer through the applicable vesting date.