Andrew Callos - 05 Mar 2026 Form 4 Insider Report for CYTOKINETICS INC (CYTK)

Role: EVP, Chief Commercial Officer
Signature: /s/ John O. Faurescu, attorney-in-fact for Mr. Callos
Issuer symbol: CYTK
Transactions as of: 05 Mar 2026
Net transactions value: -$1,608,730
Form type: 4
Filing time: 05 Mar 2026, 16:27:52 UTC
Previous filing: 02 Mar 2026
Next filing: 10 Mar 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Callos Andrew	EVP, Chief Commercial Officer	350 OYSTER POINT BLVD, SOUTH SAN FRANCISCO	/s/ John O. Faurescu, attorney-in-fact for Mr. Callos	05 Mar 2026	0001852129

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership
transaction	CYTK	Common Stock	Options Exercise		+11,000	+17%	$39.13^*	76,440	05 Mar 2026	Direct
transaction	CYTK	Common Stock	Sale	$928,050	-15,000	-20%	$61.87	61,440	05 Mar 2026	Direct
transaction	CYTK	Common Stock	Sale	$680,680	-11,000	-18%	$61.88	50,440	05 Mar 2026	Direct
transaction	CYTK	Common Stock	Options Exercise		+15,000	+30%	$23.26^*	65,440	05 Mar 2026	Direct

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	CYTK	Non-Qualified Stock Option (Right to Buy)	Options Exercise		-11,000	-31%	$0.000000^*	24,403	05 Mar 2026	Common Stock	11,000	$39.13	Direct
transaction	CYTK	Non-Qualified Stock Option (Right to Buy)	Options Exercise		-15,000	-18%	$0.000000^*	69,000	05 Mar 2026	Common Stock	15,000	$23.26	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id	Content
F1	Stock options will vest over 4 years from the date of the grant, with 1/4th of the shares underlying the reporting person's option vesting on the one-year anniversary of the grant date and the remaining shares thereafter vesting monthly at a rate of 1/48th of the shares underlying the reporting person's option over the subsequent 36 months, subject to the reporting person's continued employment with the Issuer.

Content

Stock options will vest over 4 years from the date of the grant, with 1/4th of the shares underlying the reporting person's option vesting on the one-year anniversary of the grant date and the remaining shares thereafter vesting monthly at a rate of 1/48th of the shares underlying the reporting person's option over the subsequent 36 months, subject to the reporting person's continued employment with the Issuer.