Andrew Callos - 05 Dec 2025 Form 4 Insider Report for CYTOKINETICS INC (CYTK)

Signature
/s/ John O. Faurescu, attorney-in-fact for Mr. Callos
Issuer symbol
CYTK
Transactions as of
05 Dec 2025
Net transactions value
-$1,685,454
Form type
4
Filing time
05 Dec 2025, 17:35:15 UTC
Previous filing
05 Dec 2025
Next filing
08 Dec 2025

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Callos Andrew EVP, Chief Commercial Officer 350 OYSTER POINT BLVD, SOUTH SAN FRANCISCO /s/ John O. Faurescu, attorney-in-fact for Mr. Callos 05 Dec 2025 0001852129

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction CYTK Common Stock Options Exercise $348,900 +15,000 +30% $23.26 65,660 05 Dec 2025 Direct
transaction CYTK Common Stock Options Exercise $430,430 +11,000 +17% $39.13 76,660 05 Dec 2025 Direct
transaction CYTK Common Stock Options Exercise $596,737 +15,858 +21% $37.63 92,518 05 Dec 2025 Direct
transaction CYTK Common Stock Options Exercise $399,932 +10,628 +11% $37.63 103,146 05 Dec 2025 Direct
transaction CYTK Common Stock Sale $3,461,452 -52,486 -51% $65.95 50,660 05 Dec 2025 Direct

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction CYTK Non-Qualified Stock Option (Right to Buy) Options Exercise $0 -15,000 -12% $0.000000 114,000 05 Dec 2025 Common Stock 15,000 $23.26 Direct
transaction CYTK Non-Qualified Stock Option (Right to Buy) Options Exercise $0 -11,000 -23% $0.000000 36,445 05 Dec 2025 Common Stock 11,000 $39.13 Direct
transaction CYTK Non-Qualified Stock Option (Right to Buy) Options Exercise $0 -15,858 -50% $0.000000 15,857 05 Dec 2025 Common Stock 15,858 $37.63 Direct
transaction CYTK Incentive Stock Option (Right to Buy) Options Exercise $0 -10,628 -80% $0.000000 2,657 05 Dec 2025 Common Stock 10,628 $37.63 Direct
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).