| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| BROWN JAMES E | President & CEO, Director | C/O DURECT CORPORATION, 10240 BUBB ROAD, CUPERTINO | /s/ James E. Brown | 11 Sep 2025 | 0001134620 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | DRRX | Common Stock | Options Exercise | $171,500 | +131,923 | +47% | $1.30 | 415,335 | 09 Sep 2025 | Direct | |
| transaction | DRRX | Common Stock | Options Exercise | $169,000 | +130,000 | +31% | $1.30 | 545,335 | 10 Sep 2025 | Direct | |
| holding | DRRX | Common Stock | 8,000 | 09 Sep 2025 | by Brown 2006 Trust | F1 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | DRRX | Stock Option (right to buy) | Options Exercise | $0 | -131,923 | -36% | $0.000000 | 233,077 | 09 Sep 2025 | Common Stock | 131,923 | $1.30 | Direct | F2 |
| transaction | DRRX | Stock Option (right to buy) | Options Exercise | $0 | -130,000 | -56% | $0.000000 | 103,077 | 10 Sep 2025 | Common Stock | 130,000 | $1.30 | Direct | F2 |
| Id | Content |
|---|---|
| F1 | Held by the Brown Family Trust DTD 5/10/2006. |
| F2 | The option will vest and become exercisable in installments of one-sixteenth (1/16) of the total number of shares at the end of each three-month period following the grant date, subject to the Reporting Person providing continuous service to the Issuer through the applicable vesting date. |