| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Maderis Gail J | Director | C/O DURECT CORPORATION, 10240 BUBB ROAD, CUPERTINO | /s/ Gail J. Maderis | 11 Sep 2025 | 0001503147 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | DRRX | Common Stock | Options Exercise | $6,710 | +5,500 | $1.22 | 5,500 | 09 Sep 2025 | Direct | ||
| holding | DRRX | Common Stock | 20,000 | 09 Sep 2025 | By Gail J. Maderis Revocable Trust dtd 04-08- 2013 Gail Maderis TTEE |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | DRRX | Stock Option (right to buy) | Options Exercise | $0 | -5,500 | -100% | $0.000000 | 0 | 09 Sep 2025 | Common Stock | 5,500 | $1.22 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | 100% of the total number of shares subject to this option grant shall vest and become exercisable on the day before the first anniversary of the date of grant, subject to the Reporting Person continuing to provide services to the Company through the vesting date. |