Sanjiv Patel - 09 Jul 2025 Form 4 Insider Report for Relay Therapeutics, Inc. (RLAY)

Role: President and CEO, Director
Signature: /s/ Brian Adams, as Attorney-in-Fact
Issuer symbol: RLAY
Transactions as of: 09 Jul 2025
Net transactions value: -$219,123
Form type: 4
Filing time: 10 Jul 2025, 16:55:22 UTC
Previous filing: 01 Jul 2025
Next filing: 04 Nov 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Patel Sanjiv	President and CEO, Director	C/O RELAY THERAPEUTICS, INC., 60 HAMPSHIRE STREET, CAMBRIDGE	/s/ Brian Adams, as Attorney-in-Fact	10 Jul 2025	0001816210

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	RLAY	Common Stock	Sale	$152,582	-42,740	-5.2%	$3.57	783,927	09 Jul 2025	Direct	F1, F2
transaction	RLAY	Common Stock	Sale	$66,541	-18,639	-2.4%	$3.57	765,288	09 Jul 2025	Direct	F3, F4
holding	RLAY	Common Stock						199,548	09 Jul 2025	By The Patel Family Irrevocable Trust of 2019	F5
holding	RLAY	Common Stock						687,355	09 Jul 2025	By The SSP Irrevocable Trust of 2020	F5

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 95,295 shares of restricted stock units ("RSUs") on July 8, 2025. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.
F2	Includes 315,265 shares underlying RSUs.
F3	Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 41,558 shares of RSUs on July 8, 2025. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.
F4	Includes 273,707 shares underlying RSUs.
F5	These shares are held in irrevocable trusts for the benefit of the reporting person's family members. An independent trustee is trustee of the trusts. The reporting person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.