EcoR1 Capital, LLC - 26 Jun 2025 Form 4 Insider Report for Zymeworks Inc. (ZYME)

Role
Director, 10%+ Owner
Signature
/s/ Oleg Nodelman, Individually and as Manager of EcoR1 Capital, LLC
Issuer symbol
ZYME
Transactions as of
26 Jun 2025
Net transactions value
-$12.46
Form type
4
Filing time
27 Jun 2025, 17:50:21 UTC
Previous filing
19 May 2025
Next filing
30 Jul 2025
SEC
View on sec.gov

Reporting Owners (2)

Name Relationship Address Signature Signature date CIK
EcoR1 Capital, LLC Director, 10%+ Owner 357 TEHAMA STREET #3, SAN FRANCISCO /s/ Oleg Nodelman, Individually and as Manager of EcoR1 Capital, LLC 27 Jun 2025 0001587114
NODELMAN OLEG Director, 10%+ Owner 357 TEHAMA STREET #3, SAN FRANCISCO /s/ Oleg Nodelman, Individually and as Manager of EcoR1 Capital, LLC 27 Jun 2025 0001454385

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction ZYME Common Stock Exercise of in-the-money or at-the-money derivative security $509 +5,086,480 +28% $0.000100 22,970,388 26 Jun 2025 See Note F1, F2, F3
transaction ZYME Common Stock Tax liability $521 -41 -0% $12.71 22,970,388 26 Jun 2025 See Note F1, F3, F4

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction ZYME Pre-Funded Warrants (right to acquire) Exercise of in-the-money or at-the-money derivative security $0 -5,086,521 -100% $0.000000 0 26 Jun 2025 Common Stock 5,086,521 $0.000100 See note F1, F5, F6
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.
F2 Qualified Fund acquired 4,818,424 shares of Common Stock in connection with the exercise of the pre-funded warrants.
F3 After the transactions reported herein, Qualified Fund held 21,582,563 shares of the Issuer's Common Stock.
F4 On June 26, 2025,the reporting persons exercised pre-funded warrants to purchase 5,086,521 shares of the Issuer's Common Stock for $0.0001 per share. The reporting persons paid the exercise price on a cashless basis, resulting in the Issuer withholding 41 of the warrant shares (including 38 warrant shares issuable to Qualified Fund) to pay the exercise price and issuing to the reporting persons the remaining 5,086,480 shares.
F5 Qualified Fund exercised 4,818,462 of the pre-funded warrants reported in this transaction.
F6 The pre-funded warrants did not have an expiration date.

Remarks:

Mr. Nodelman is a director of the Issuer. Scott Platshon, an employee of EcoR1, also serves as a director of the Issuer and was nominated for the board by EcoR1 and the Funds.