| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 10%+ Owner | 357 TEHAMA STREET #3, SAN FRANCISCO | /s/ Oleg Nodelman, Manager of EcoR1 Capital, LLC | 13 May 2025 | 0001587114 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| holding | ITOS | Common Stock | 5,730,000 | 13 May 2025 | See Note | F1, F2 |
| Id | Content |
|---|---|
| F1 | The reporting persons are EcoR1 Capital, LLC ("EcoR1"), EcoR1 Capital Fund Qualified L.P. ("Qualified Fund") and Oleg Nodelman. EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself Mr. Nodelman and Qualified Fund. The reporting persons are filng this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 3d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The reporting persons disclaim beneficial ownership of such securities except to the extent of their respective pecuniary interests therein. |
| F2 | Qualified Fund beneficially owns 5,371,661 shares of Common Stock. |