George Magrath - 01 Nov 2025 Form 4/A - Amendment Insider Report for Opus Genetics, Inc. (IRD)

Role: Chief Executive Officer, Director
Signature: /s/ Amy Rabourn, by Power of Attorney
Issuer symbol: IRD
Transactions as of: 01 Nov 2025
Net transactions value: -$69,805
Form type: 4/A - Amendment
Filing time: 05 Nov 2025, 16:06:41 UTC
Date Of Original Report: 04 Nov 2025
Previous filing: 26 Mar 2025
Next filing: 26 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Magrath George	Chief Executive Officer, Director	C/O OPUS GENETICS, INC., 8 DAVIS DRIVE, SUITE 220, DURHAM	/s/ Amy Rabourn, by Power of Attorney	05 Nov 2025	0001999390

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	IRD	Common Stock	Tax liability	$69,805	-30,350	-2.3%	$2.30	1,291,654	01 Nov 2025	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The Issuer withheld the shares reported on this line to satisfy tax withholding obligations that arose in connection with a vesting and settlement event from a restricted stock units award. Not an open market sale of securities.

Remarks:

This amendment to the Form 4 the Reporting Person filed on November 4, 2025, is being filed solely to add a footnote disclosing that the reported transaction was not an open market sale of securities.