David Altshuler - Aug 8, 2022 Form 4 Insider Report for VERTEX PHARMACEUTICALS INC / MA (VRTX)

Role: EVP, Global Research and CSO
Signature: /s/ Joy Liu, Attorney-in-Fact
Stock symbol: VRTX
Transactions as of: Aug 8, 2022
Transactions value $: -$136,930
Form type: 4
Date filed: 8/10/2022, 04:06 PM
Previous filing: Jul 21, 2022
Next filing: Nov 9, 2022
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	VRTX	Common Stock	Options Exercise	$245K	+1.3K	+3.61%	$187.53	37.4K	Aug 8, 2022	Direct
transaction	VRTX	Common Stock	Sale	-$64.5K	-222	-0.59%	$290.32	37.2K	Aug 8, 2022	Direct	F1, F2, F3
transaction	VRTX	Common Stock	Sale	-$124K	-424	-1.14%	$291.53	36.7K	Aug 8, 2022	Direct	F1, F2, F4
transaction	VRTX	Common Stock	Sale	-$61.5K	-210	-0.57%	$293.02	36.5K	Aug 8, 2022	Direct	F1, F2, F5
transaction	VRTX	Common Stock	Sale	-$88.8K	-302	-0.83%	$293.99	36.2K	Aug 8, 2022	Direct	F1, F2, F6
transaction	VRTX	Common Stock	Sale	-$43.1K	-146	-0.4%	$295.14	36.1K	Aug 8, 2022	Direct	F1, F2, F7

Showing 1 to 6 of 6 entries

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	VRTX	Stock Option (Right to Buy)	Options Exercise	$0	-1.3K	-33.34%	$0.00	2.61K	Aug 8, 2022	Common Stock	1.3K	$187.53	Direct	F8

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Transaction made pursuant to Mr. Altshuler's company approved trading plan under Rule 10b5-1.
F2	Mr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
F3	Open market sales reported on this line occurred at a weighted average price of $290.32 (range $290.05 to $290.64).
F4	Open market sales reported on this line occurred at a weighted average price of $291.53 (range $291.06 to $291.91).
F5	Open market sales reported on this line occurred at a weighted average price of $293.02 (range $292.41 to $293.36).
F6	Open market sales reported on this line occurred at a weighted average price of $293.99 (range $293.58 to $294.26).
F7	Open market sales reported on this line occurred at a weighted average price of $295.14 (range $294.74 to $295.53).
F8	The option vests in 16 quarterly installments from 2/6/2019.