| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ITOS | Common Stock | Sale | $20,626,183 | -432,903 | -10% | $47.65 | 3,912,113 | 03 Jan 2022 | Direct | F1, F3 |
| transaction | ITOS | Common Stock | Sale | $1,949,355 | -39,481 | -1% | $49.37 | 3,872,632 | 03 Jan 2022 | Direct | F1, F4 |
| transaction | ITOS | Common Stock | Sale | $869,534 | -17,173 | -0.44% | $50.63 | 3,855,459 | 03 Jan 2022 | Direct | F1 |
| transaction | ITOS | Common Stock | Sale | $1,112,245 | -23,353 | -32% | $47.63 | 48,890 | 03 Jan 2022 | Direct | F2, F3 |
| transaction | ITOS | Common Stock | Sale | $83,049 | -1,682 | -3.4% | $49.37 | 47,208 | 03 Jan 2022 | Direct | F2, F4 |
| transaction | ITOS | Common Stock | Sale | $37,013 | -731 | -1.5% | $50.63 | 46,477 | 03 Jan 2022 | Direct | F2 |
| transaction | ITOS | Common Stock | Sale | $3,684,355 | -88,054 | -2.3% | $41.84 | 3,767,405 | 04 Jan 2022 | Direct | F1, F5 |
| transaction | ITOS | Common Stock | Sale | $406,110 | -9,366 | -0.25% | $43.36 | 3,758,039 | 04 Jan 2022 | Direct | F1, F6 |
| transaction | ITOS | Common Stock | Sale | $1,479,772 | -33,297 | -0.89% | $44.44 | 3,724,742 | 04 Jan 2022 | Direct | F1 |
| transaction | ITOS | Common Stock | Sale | $340,310 | -7,483 | -0.2% | $45.48 | 3,717,259 | 04 Jan 2022 | Direct | F1 |
| transaction | ITOS | Common Stock | Sale | $1,239,486 | -29,623 | -64% | $41.84 | 16,854 | 04 Jan 2022 | Direct | F2, F5 |
| transaction | ITOS | Common Stock | Sale | $136,062 | -3,138 | -19% | $43.36 | 13,716 | 04 Jan 2022 | Direct | F2, F6 |
| transaction | ITOS | Common Stock | Sale | $497,701 | -11,199 | -82% | $44.44 | 2,517 | 04 Jan 2022 | Direct | F2 |
| transaction | ITOS | Common Stock | Sale | $114,467 | -2,517 | -100% | $45.48 | 0 | 04 Jan 2022 | Direct | F2 |
| Id | Content |
|---|---|
| F1 | These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"), which may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, (ii) Boxer Asset Management Inc. ("Boxer Management"), (iii) MVA Investors, LLC ("MVA Investors"), (iv) Aaron I. Davis, and (v) Joseph C. Lewis (collectively, the "Boxer Group"). These securities are owned indirectly by Boxer Management and Joseph C. Lewis, by virtue of their ownership of Boxer Capital. Each member of the Boxer Group other than Boxer Capital disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein. |
| F2 | These securities are owned directly by MVA Investors, which may be deemed to be a member of the Boxer Group for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended. Aaron I. Davis is a member of and has voting and dispositive power over securities held by MVA Investors. Each member of the Boxer Group other than MVA Investors and Aaron I. Davis disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein. Following the completion of the transactions reported in this Form 4, MVA Investors no longer holds any securities of the issuer and, therefore, as of January 4, 2022, is no longer a member of the Boxer Group |
| F3 | Reflects the weighted average sale price. The reporting person effected multiple same-way open market sale transactions on the same day at different prices through a trade order executed by a broker dealer. The reporting person reported on a single line all such transactions that occurred within a one dollar price range. The reporting person hereby undertakes to provide upon request by the Securities and Exchange Commission staff, the issuer, or a shareholder of the issuer, full information regarding the number of shares sold at each separate price. The range of prices for such transaction is $47.4904 to $47.8617. |
| F4 | Reflects the weighted average sale price. The reporting person effected multiple same-way open market sale transactions on the same day at different prices through a trade order executed by a broker dealer. The reporting person reported on a single line all such transactions that occurred within a one dollar price range. The reporting person hereby undertakes to provide upon request by the Securities and Exchange Commission staff, the issuer, or a shareholder of the issuer, full information regarding the number of shares sold at each separate price. The range of prices for such transaction is $49.2035 to $50.1716. |
| F5 | Reflects the weighted average sale price. The reporting person effected multiple same-way open market sale transactions on the same day at different prices through a trade order executed by a broker dealer. The reporting person reported on a single line all such transactions that occurred within a one dollar price range. The reporting person hereby undertakes to provide upon request by the Securities and Exchange Commission staff, the issuer, or a shareholder of the issuer, full information regarding the number of shares sold at each separate price. The range of prices for such transaction is $41.4811 to $42.1440. |
| F6 | Reflects the weighted average sale price. The reporting person effected multiple same-way open market sale transactions on the same day at different prices through a trade order executed by a broker dealer. The reporting person reported on a single line all such transactions that occurred within a one dollar price range. The reporting person hereby undertakes to provide upon request by the Securities and Exchange Commission staff, the issuer, or a shareholder of the issuer, full information regarding the number of shares sold at each separate price. The range of prices for such transaction is $42.6291 to $43.4221. |