Mohamed Khairie Issa - 15 Jul 2025 Form 4 Insider Report for INCYTE CORP (INCY)

Role: EVP, Head of US Oncology
Signature: /s/ Elizabeth Feeney, Attorney-In-Fact
Issuer symbol: INCY
Transactions as of: 15 Jul 2025
Net transactions value: $0
Form type: 4
Filing time: 17 Jul 2025, 16:04:17 UTC
Previous filing: 02 Jul 2025
Next filing: 08 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Issa Mohamed Khairie	EVP, Head of US Oncology	1801 AUGUSTINE CUT-OFF, WILMINGTON	/s/ Elizabeth Feeney, Attorney-In-Fact	17 Jul 2025	0002050035

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	INCY	Common Stock	Award	$0	+8,769	+11%	$0.000000	85,252	15 Jul 2025	Direct	F1, F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	INCY	Performance Shares	Award	$0	+21,923		$0.000000	21,923	15 Jul 2025	Common Stock	21,923		Direct	F3
transaction	INCY	Employee Stock Option (right to buy)	Award	$0	+19,735		$0.000000	19,735	15 Jul 2025	Common Stock	19,735	$68.25	Direct	F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis.
F2	Including the July 15, 2025 grant, this includes an aggregate of 85,252 shares of common stock issuable pursuant to previously reported RSUs that have not vested.
F3	Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2025 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer.
F4	The July 15, 2025 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years.