Joy Liu - 01 Mar 2026 Form 3 Insider Report for VERTEX PHARMACEUTICALS INC / MA (VRTX)

Role: EVP and Chief Legal Officer
Signature: /s/ Christiana Stevenson, Attorney-in-Fact
Issuer symbol: VRTX
Transactions as of: 01 Mar 2026
Net transactions value: $0
Form type: 3
Filing time: 03 Mar 2026, 16:41:53 UTC
Previous filing: 17 Aug 2022
Next filing: 04 Mar 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Liu Joy	EVP and Chief Legal Officer	C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON	/s/ Christiana Stevenson, Attorney-in-Fact	03 Mar 2026	0001847529

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
holding	VRTX	Common Stock						23,703	01 Mar 2026	Direct

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
holding	VRTX	Stock Option (Right to Buy)							01 Mar 2026	Common Stock	7,044	$155.57	Direct	F1
holding	VRTX	Stock Option (Right to Buy)							01 Mar 2026	Common Stock	5,363	$187.53	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Fully vested.

Remarks:

Exhibit 24 - Power of Attorney