| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| WAGNER CHARLES F JR | EVP, CO & FO | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 26 Feb 2026 | 0001223348 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Tax liability | $846,032 | -1,744 | -3.6% | $485.11 | 47,042 | 24 Feb 2026 | Direct |