Kristen Ambrose - 17 Feb 2026 Form 4 Insider Report for VERTEX PHARMACEUTICALS INC / MA (VRTX)

Signature
/s/ Christiana Stevenson, Attorney-in-Fact
Issuer symbol
VRTX
Transactions as of
17 Feb 2026
Net transactions value
-$1,353,580
Form type
4
Filing time
19 Feb 2026, 16:03:25 UTC
Previous filing
18 Feb 2026
Next filing
26 Feb 2026

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Ambrose Kristen SVP & Chief Accounting Officer C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON /s/ Christiana Stevenson, Attorney-in-Fact 19 Feb 2026 0001856587

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction VRTX Common Stock Award $0 +1,809 +21% $0.000000 10,543 17 Feb 2026 Direct F1
transaction VRTX Common Stock Tax liability $289,282 -598 -5.7% $483.75 9,945 17 Feb 2026 Direct
transaction VRTX Common Stock Sale $762,089 -1,557 -16% $489.46 8,388 17 Feb 2026 Direct F2
transaction VRTX Common Stock Sale $302,208 -638 -7.6% $473.68 7,750 18 Feb 2026 Direct F2
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 Restricted stock unit award that vests in installments beginning on February 20, 2027.
F2 Transaction made pursuant to Ms. Ambrose's company approved trading plan under Rule 10b5-1, which was entered into on 08/08/2025.