Ourania Tatsis - 13 Feb 2026 Form 4 Insider Report for VERTEX PHARMACEUTICALS INC / MA (VRTX)

Signature
/s/ Christiana Stevenson, Attorney-in-Fact
Issuer symbol
VRTX
Transactions as of
13 Feb 2026
Net transactions value
-$2,605,424
Form type
4
Filing time
18 Feb 2026, 16:43:59 UTC
Previous filing
12 Feb 2026
Next filing
19 Feb 2026

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Tatsis Ourania EVP, Chief Reg. & Quality Off. C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON /s/ Christiana Stevenson, Attorney-in-Fact 18 Feb 2026 0001789815

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction VRTX Common Stock Tax liability $1,855,439 -3,804 -7.4% $487.76 47,632 13 Feb 2026 Direct
transaction VRTX Common Stock Sale $749,985 -1,500 -3.1% $499.99 46,132 13 Feb 2026 Direct F1, F2, F3
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 Transaction made pursuant to Dr. Tatsis' company approved trading plan under Rule 10b5-1, which was entered into on 08/21/2025.
F2 Open market sales reported on this line occurred at a weighted average price of $499.99 (range $499.99 to $500.04).
F3 Dr. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.