| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Sachdev Amit | EVP Chief Patient & Ext Af Off | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 18 Feb 2026 | 0001406338 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Tax liability | $1,730,572 | -3,548 | -5.1% | $487.76 | 65,393 | 13 Feb 2026 | Direct | |
| holding | VRTX | Common Stock | 9,301 | 13 Feb 2026 | Held in Trust | ||||||
| holding | VRTX | Common Stock | 882 | 13 Feb 2026 | 401(k) |