| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| McKechnie Duncan | EVP, Chief Commercial Officer | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 12 Feb 2026 | 0002062139 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Tax liability | $527,898 | -1,127 | -4.9% | $468.41 | 21,811 | 10 Feb 2026 | Direct |