| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Kewalramani Reshma | CEO & President, Director | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 12 Feb 2026 | 0001735944 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Tax liability | $3,886,398 | -8,297 | -5.4% | $468.41 | 146,528 | 10 Feb 2026 | Direct |