| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Sachdev Amit | EVP Chief Patient & Ext Af Off | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 26 Jan 2026 | 0001406338 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Award | $0 | +7,866 | +13% | $0.000000 | 67,115 | 22 Jan 2026 | Direct | F1 |
| transaction | VRTX | Common Stock | Award | $0 | +3,883 | +5.8% | $0.000000 | 70,998 | 22 Jan 2026 | Direct | F2 |
| holding | VRTX | Common Stock | 882 | 22 Jan 2026 | 401(k) | ||||||
| holding | VRTX | Common Stock | 9,301 | 22 Jan 2026 | Held in Trust |
| Id | Content |
|---|---|
| F1 | Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2023 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 01/22/2026 and the shares will vest on 02/13/2026. |
| F2 | Represents earned performance shares with respect to a performance stock unit award granted on 02/12/2025 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 01/22/2026 and the shares will vest in installments beginning on 02/24/2026. |