| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| ALTSHULER DAVID | EVP, Chief Scientific Officer | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 26 Jan 2026 | 0001550395 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Award | $0 | +7,866 | +34% | $0.000000 | 31,149 | 22 Jan 2026 | Direct | F1 |
| transaction | VRTX | Common Stock | Award | $0 | +3,328 | +11% | $0.000000 | 34,477 | 22 Jan 2026 | Direct | F2 |
| Id | Content |
|---|---|
| F1 | Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2023 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 01/22/2026 and the shares will vest on 02/13/2026. |
| F2 | Represents earned performance shares with respect to a performance stock unit award granted on 02/12/2025 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 01/22/2026 and the shares will vest in installments beginning on 02/24/2026. |