| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| SACHS BRUCE I | Director | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 20 Jan 2026 | 0001197036 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Deferred Stock Units | Award | $47,500 | +107 | +0.69% | $443.56 | 15,565 | 15 Jan 2026 | Common Stock | 107 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death. |