| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| CARNEY LLOYD | Director | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 20 Nov 2025 | 0001204424 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Gift | $0 | -800 | -11% | $0.000000 | 6,315 | 19 Nov 2025 | Direct |