| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| SACHS BRUCE I | Director | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 07 Aug 2025 | 0001197036 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Purchase | $636,214 | +1,634 | +4.1% | $389.36 | 41,634 | 06 Aug 2025 | Direct | F1, F2 |
| transaction | VRTX | Common Stock | Purchase | $1,312,201 | +3,366 | +8.1% | $389.84 | 45,000 | 06 Aug 2025 | Direct | F2, F3 |
| Id | Content |
|---|---|
| F1 | Open market purchases reported on this line occurred at a weighted average price of $389.36 (range $388.61 to $389.60). |
| F2 | Mr. Sachs undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares purchased at each separate price. |
| F3 | Open market purchases reported on this line occurred at a weighted average price of $389.84 (range $389.61 to $390.00). |