Suketu Upadhyay - 15 Jul 2025 Form 4 Insider Report for VERTEX PHARMACEUTICALS INC / MA (VRTX)

Role: Director
Signature: /s/ Christiana Stevenson, Attorney-in-Fact
Issuer symbol: VRTX
Transactions as of: 15 Jul 2025
Net transactions value: +$35,625
Form type: 4
Filing time: 17 Jul 2025, 16:09:19 UTC
Previous filing: 05 May 2025
Next filing: 17 Oct 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Upadhyay Suketu	Director	C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON	/s/ Christiana Stevenson, Attorney-in-Fact	17 Jul 2025	0001533149

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	VRTX	Deferred Stock Units	Award	$35,625	+76	+3.1%	$469.34	2,552	15 Jul 2025	Common Stock	76		Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.