Stuart A. Arbuckle - 13 May 2025 Form 4 Insider Report for VERTEX PHARMACEUTICALS INC / MA (VRTX)

Role: EVP, COO
Signature: /s/ Christiana Stevenson, Attorney-in-Fact
Issuer symbol: VRTX
Transactions as of: 13 May 2025
Net transactions value: $0
Form type: 4
Filing time: 15 May 2025, 16:10:28 UTC
Previous filing: 28 Feb 2025
Next filing: 23 Jun 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Arbuckle Stuart A	EVP, COO	C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON	/s/ Christiana Stevenson, Attorney-in-Fact	15 May 2025	0001557290

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	VRTX	Common Stock	Award	$0	+37,622	+60%	$0.000000	100,611	13 May 2025	Direct	F1
holding	VRTX	Common Stock						140	13 May 2025	401(k)

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents earned performance shares with respect to a performance stock unit award granted on 12/06/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 05/13/2025 and the shares will vest on 07/01/2025.