SPHERA FUNDS MANAGEMENT LTD.

Q4 2017 13F Holdings Report, Options Holdings

Signature - Title
Oshrat Levi - Chief Financial Officer
Location
Tel Aviv, Israel
Options holdings as of
December 31, 2017
Notional value $
$228M
Number of holdings
6
Date filed
2/12/2018, 02:44 PM
Description
All US holdings of this investor are reported in this report.
Previous filing
Q3 2017 - Nov 27, 2017
Stock holdings
Showing options holdings, see here for stock holdings
Sym Company Class Option Share Change Activity * Price $ Shares Notional Value
Filing 2017 Q4 compared to 2017 Q3 - Restatement by default.
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.

Person Signing this Report on Behalf of Reporting Manager:

Name Title City, State Date
Israel Mor Partner Tel Aviv, Israel 2/12/2018

Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.

Other Included Managers (2):

Num Name Location File Number
1 Sphera Global Healthcare GP Ltd. Tel Aviv, Israel 028-15864
2 Sphera Global Healthcare Management LP Tel Aviv, Israel 028-15865