13F Filings History of SR ONE CAPITAL MANAGEMENT, LP

Latest 13F report
Q4 2025 - 12 Feb 2026
Value $
$706,376,583
Signature - Title
Sasha Keough - General Counsel and CCO
Location
Redwood City, CA
Summary
This page shows a list of all the recent 13F filings made by SR ONE CAPITAL MANAGEMENT, LP. Form 13F is required to be filed within 45 days of the end of a calendar quarter. SR ONE CAPITAL MANAGEMENT, LP reported 13 stock holdings with total value $706,376,583 as of Q4 2025. Top holdings included ZBIO, ACLX, CRSP, DSGN, and MLYS.

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Holdings Value
Quarter Holdings Value $ Bought Sold Net Top Holdings Form Type Filing Time
Q4 2025 13 $706,376,583 +$14,115,701 -$19,958,302 -$5,842,601 ZBIO, ACLX, CRSP, DSGN, MLYS 13F-HR 12 Feb 2026, 16:22
Q3 2025 12 $691,412,158 +$64,149,716 -$41,301,834 +$22,847,882 ACLX, CRSP, ZBIO, MLYS, ORIC 13F-HR 12 Nov 2025, 16:32
Q2 2025 13 $461,375,729 +$45,826,529 $0 +$45,826,529 ACLX, SPRY, CRSP, ZBIO, ORIC 13F-HR 14 Aug 2025, 16:33
Q1 2025 12 $389,283,283 +$23,781,618 $0 +$23,781,618 ACLX, SPRY, MLYS, ZBIO, CRSP 13F-HR 13 May 2025, 16:27
Q4 2024 11 $410,084,894 +$2,144,086 $0 +$2,144,086 ACLX, SPRY, CRSP, DSGN, ZBIO 13F-HR 13 Feb 2025, 16:23
Q3 2024 11 $498,734,988 +$93,937,728 $0 +$93,937,728 ACLX, ZBIO, SPRY, CRSP, DSGN 13F-HR 13 Nov 2024, 17:23
Q2 2024 9 $319,401,842 +$33,927,173 $0 +$33,927,173 ACLX, CRSP, SPRY, ALMS, MLYS 13F-HR 13 Aug 2024, 16:36
Q1 2024 6 $364,088,686 +$95,985,386 -$55,640,000 +$40,345,386 ACLX, CRSP, SPRY, NKTX, DSGN 13F-HR 13 May 2024, 17:22
Q4 2023 5 $238,157,392 $0 -$48,425,047 -$48,425,047 ACLX, SPRY, DSGN, MLYS, NKTX 13F-HR 12 Feb 2024, 16:00
Q3 2023 6 $195,121,366 $0 $0 $0 ACLX, MLYS, DSGN, SPRY, EFTR 13F-HR 13 Nov 2023, 11:31
Q2 2023 6 $231,907,752 $0 -$49,117,781 -$49,117,781 ACLX, DSGN, MLYS, SPRY, EFTR 13F-HR 10 Aug 2023, 12:30
Q1 2023 6 $268,461,490 +$34,634,437 $0 +$34,634,437 ACLX, DSGN, MLYS, SPRY, NKTX Restatement 19 May 2023, 12:50
Q4 2022 5 $273,944,579 +$34,906,544 $0 +$34,906,544 ACLX, DSGN, SPRY, NKTX, EFTR 13F-HR 08 Feb 2023, 11:29
Q3 2022 4 $218,746,000 $0 $0 $0 ACLX, DSGN, NKTX, EFTR 13F-HR 08 Nov 2022, 11:53
Q2 2022 4 $204,325,000 +$16,427,000 $0 +$16,427,000 ACLX, DSGN, NKTX, EFTR 13F-HR 01 Aug 2022, 17:40
Q1 2022 3 $195,335,000 +$77,110,000 $0 +$77,110,000 DSGN, ACLX, EFTR 13F-HR 10 May 2022, 15:28
Q4 2021 2 $176,950,000 $0 $0 $0 DSGN, EFTR 13F-HR 14 Feb 2022, 10:35