Quick Takeaways
- DAFNA Capital Management LLC reports institutional holdings through Form 13F filings.
- Latest reported quarter: Q4 2025.
- Latest reported holdings value: $430,518,714.
- Info
- Portfolio
13F Filings History of DAFNA Capital Management LLC
- Latest 13F report
- Q4 2025 - 17 Feb 2026
- Value $
- $430,518,714
- Notable people
- Nathan Fischel
- Signature - Title
- Nathan Fischel - CEO
- Location
- Los Angeles, CA
- Summary
- This page shows a list of all the recent 13F filings made by DAFNA Capital Management LLC. Form 13F is required to be filed within 45 days of the end of a calendar quarter. DAFNA Capital Management LLC reported 77 stock holdings with total value $430,518,714 as of Q4 2025. Top holdings included RVMD, XBI, STXS, ATRC, and CYTK.
Follow Filing Activity
Follow DAFNA Capital Management LLC and return when a new 13F portfolio filing appears.
This tracks SEC filing changes for this page using existing product update flows.
Holdings Value
What Changed
- Most recent filing was accepted on 17 Feb 2026, 13:42.
- Reported value moved from $404,785,884 to $430,518,714.
Why This Matters
- This gives a plain-language read of holdings direction before you open full quarter tables.
- Use the filing links below to verify the exact SEC source document.
Official SEC Source
Backed by Form 13F
Portfolio holdings and changes are grounded in SEC Form 13F filings.
See Original Filing| Quarter | Holdings | Value $ | Bought | Sold | Net | Top Holdings | Form Type | Filing Time |
|---|---|---|---|---|---|---|---|---|
| Q4 2025 | 77 | $430,518,714 | +$42,037,090 | -$90,960,432 | -$48,923,342 | RVMD, XBI, STXS, ATRC, CYTK | 13F-HR | 17 Feb 2026, 13:42 |
| Q3 2025 | 75 | $404,785,884 | +$23,304,011 | -$90,192,499 | -$66,888,488 | STXS, XBI, RVMD, CYTK, ATRC | 13F-HR | 14 Nov 2025, 13:51 |
| Q2 2025 | 76 | $362,250,156 | +$15,244,704 | -$24,620,337 | -$9,375,633 | XBI, STXS, RVMD, BPMC, MRUS | 13F-HR | 14 Aug 2025, 13:43 |
| Q1 2025 | 83 | $352,661,806 | +$26,728,351 | -$16,843,093 | +$9,885,258 | XBI, STXS, RVMD, MRUS, ATRC | 13F-HR | 15 May 2025, 13:02 |
| Q4 2024 | 82 | $393,410,219 | +$34,919,391 | -$17,730,969 | +$17,188,422 | XBI, STXS, RVMD, ATRC, MRUS | 13F-HR | 14 Feb 2025, 12:03 |
| Q3 2024 | 84 | $423,312,439 | +$16,209,834 | -$35,609,986 | -$19,400,152 | XBI, STXS, RVMD, CYTK, MRUS | 13F-HR | 14 Nov 2024, 14:14 |
| Q2 2024 | 83 | $418,567,508 | +$44,158,253 | -$15,562,495 | +$28,595,758 | XBI, STXS, MRUS, CYTK, RVMD | 13F-HR | 14 Aug 2024, 13:46 |
| Q1 2024 | 72 | $439,278,544 | +$34,374,706 | -$82,514,047 | -$48,139,341 | XBI, STXS, CYTK, IDYA, MRUS | 13F-HR | 15 May 2024, 14:16 |
| Q4 2023 | 76 | $417,341,689 | +$37,450,690 | -$52,238,250 | -$14,787,560 | XBI, CYTK, STXS, IDYA, SNDX | 13F-HR | 14 Feb 2024, 14:02 |
| Q3 2023 | 75 | $321,489,380 | +$40,410,395 | -$44,368,838 | -$3,958,443 | XBI, STXS, CYTK, IDYA, RVMD | 13F-HR | 14 Nov 2023, 14:29 |
| Q2 2023 | 73 | $365,729,922 | +$36,701,185 | -$35,769,313 | +$931,872 | XBI, ISEE, STXS, BPMC, RVMD | 13F-HR | 14 Aug 2023, 14:05 |
| Q1 2023 | 72 | $333,536,277 | +$26,140,670 | -$29,131,515 | -$2,990,845 | XBI, STXS, ISEE, ASND, KRTX | 13F-HR | 15 May 2023, 13:24 |
| Q4 2022 | 79 | $355,054,654 | +$31,872,217 | -$58,327,866 | -$26,455,649 | XBI, STXS, ASND, KRTX, IBB | 13F-HR | 14 Feb 2023, 14:24 |
| Q3 2022 | 87 | $370,839,000 | +$15,792,468 | -$44,188,466 | -$28,395,998 | XBI, STXS, BPMC, BHVN, ASND | 13F-HR | 14 Nov 2022, 14:14 |
| Q2 2022 | 90 | $366,898,000 | +$79,271,266 | -$19,415,876 | +$59,855,390 | XBI, STXS, BHVN, ACET, FATE | 13F-HR | 15 Aug 2022, 14:35 |
| Q1 2022 | 94 | $383,776,000 | +$93,446,165 | -$17,431,625 | +$76,014,540 | STXS, XBI, FATE, BPMC, ACET | 13F-HR | 16 May 2022, 14:22 |
| Q4 2021 | 87 | $397,677,000 | +$51,352,655 | -$38,359,424 | +$12,993,231 | STXS, BPMC, FATE, ACET, XENE | 13F-HR | 14 Feb 2022, 13:56 |
| Q3 2021 | 80 | $376,924,000 | +$35,796,641 | -$52,317,447 | -$16,520,806 | STXS, BPMC, FATE, BHVN, DRNA | 13F-HR | 15 Nov 2021, 13:52 |
| Q2 2021 | 84 | $478,152,000 | +$50,741,325 | -$32,801,246 | +$17,940,079 | STXS, FATE, DRNA, BPMC, TBPH | 13F-HR | 16 Aug 2021, 15:13 |
| Q1 2021 | 89 | $421,480,000 | +$83,545,384 | -$27,185,076 | +$56,360,308 | STXS, FATE, BPMC, DRNA, SAGE | 13F-HR | 17 May 2021, 14:02 |
| Q4 2020 | 74 | $336,078,000 | +$32,996,733 | -$82,435,647 | -$49,438,914 | STXS, FATE, BPMC, SAGE, DRNA | 13F-HR | 16 Feb 2021, 14:21 |
| Q3 2020 | 80 | $307,632,000 | +$32,348,709 | -$57,313,231 | -$24,964,522 | STXS, IMMU, BPMC, FATE, ARCT | 13F-HR | 16 Nov 2020, 13:59 |
| Q2 2020 | 87 | $346,509,000 | +$57,455,022 | -$53,254,040 | +$4,200,982 | STXS, BPMC, FATE, ARNA, DRNA | 13F-HR | 14 Aug 2020, 13:52 |
| Q1 2020 | 80 | $239,627,000 | +$48,755,366 | -$31,338,148 | +$17,417,218 | STXS, BPMC, FATE, GLPG, DXCM | 13F-HR | 15 May 2020, 15:05 |
| Q4 2019 | 81 | $291,332,000 | +$20,880,804 | -$55,545,786 | -$34,664,982 | STXS, PRQR, ATRC, ARQL, BPMC | 13F-HR | 14 Feb 2020, 16:01 |
| Q3 2019 | 89 | $265,897,000 | +$33,971,727 | -$15,086,393 | +$18,885,334 | STXS, SAGE, ALDR, BPMC, GLPG | 13F-HR | 14 Nov 2019, 16:59 |
| Q2 2019 | 87 | $266,028,000 | +$43,550,553 | -$11,549,100 | +$32,001,453 | STXS, SAGE, BPMC, ATRC, ALDR | 13F-HR | 14 Aug 2019, 14:39 |
| Q1 2019 | 79 | $231,803,000 | +$31,206,540 | -$55,479,680 | -$24,273,140 | STXS, SAGE, BPMC, ATRC, ALDR | 13F-HR | 15 May 2019, 14:49 |
| Q4 2018 | 83 | $201,092,000 | +$24,355,345 | -$10,260,437 | +$14,094,908 | LOXO, STXS, SAGE, ATRC, NXTM | 13F-HR | 14 Feb 2019, 15:18 |
| Q3 2018 | 75 | $243,521,000 | +$22,686,474 | -$14,650,629 | +$8,035,845 | LOXO, STXS, SAGE, ATRC, NXTM | 13F-HR | 14 Nov 2018, 13:37 |
| Q2 2018 | 75 | $213,579,000 | +$23,055,651 | -$42,557,043 | -$19,501,392 | LOXO, SAGE, STXS, AERI, NXTM | 13F-HR | 10 Aug 2018, 19:31 |
| Q1 2018 | 75 | $205,558,000 | +$47,426,500 | -$49,291,010 | -$1,864,510 | LOXO, SAGE, STXS, BPMC, ATRC | 13F-HR | 15 May 2018, 12:52 |
| Q4 2017 | 72 | $185,688,000 | +$40,216,686 | -$15,168,554 | +$25,048,132 | LOXO, BPMC, ATRC, AERI, ARGX | 13F-HR | 13 Feb 2018, 17:48 |
| Q3 2017 | 73 | $161,052,000 | +$27,015,624 | -$26,215,872 | +$799,752 | LOXO, ATRC, BGNE, IMMU, BCRX | 13F-HR | 14 Nov 2017, 15:37 |
| Q2 2017 | 75 | $139,921,000 | +$22,104,976 | -$9,150,599 | +$12,954,377 | LOXO, ATRC, IMMU, AERI, NXTM | 13F-HR | 14 Aug 2017, 16:41 |
| Q1 2017 | 72 | $118,230,000 | +$25,189,683 | -$28,103,012 | -$2,913,329 | LOXO, ATRC, NXTM, ALDR, BCRX | 13F-HR | 15 May 2017, 12:09 |
| Q4 2016 | 66 | $113,534,000 | +$19,873,219 | -$43,138,064 | -$23,264,845 | ATRC, NXTM, ALDR, LOXO, GLPG | 13F-HR | 14 Feb 2017, 14:44 |
| Q3 2016 | 74 | $143,580,000 | +$25,611,512 | -$41,870,268 | -$16,258,756 | VTAE, CYNA, ATRC, NXTM, TNDM | 13F-HR | 14 Nov 2016, 13:00 |
| Q2 2016 | 94 | $125,363,000 | +$26,535,623 | -$24,612,161 | +$1,923,462 | NXTM, ATRC, VTAE, DERM, ABBV | 13F-HR | 15 Aug 2016, 16:34 |
| Q1 2016 | 93 | $115,860,000 | +$41,305,642 | -$11,460,931 | +$29,844,711 | ATRC, ABBV, NXTM, VTAE, RIGL | 13F-HR | 16 May 2016, 13:35 |
| Q4 2015 | 77 | $112,179,000 | +$19,069,744 | -$17,638,083 | +$1,431,661 | ATRC, NXTM, ABBV, MRNS, PODD | 13F-HR | 12 Feb 2016, 17:00 |
| Q3 2015 | 88 | $100,779,000 | +$15,061,799 | -$23,588,692 | -$8,526,893 | ATRC, ABBV, NXTM, ZSPH, ACHN | 13F-HR | 13 Nov 2015, 13:23 |
| Q2 2015 | 76 | $117,321,000 | +$33,888,839 | -$51,719,404 | -$17,830,565 | ATRC, ABBV, NXTM, ACHN, RIGL | 13F-HR | 14 Aug 2015, 14:47 |
| Q1 2015 | 70 | $130,246,000 | +$19,330,001 | -$39,872,628 | -$20,542,627 | PCYC, ATRC, ASPX, NXTM, DSCO | 13F-HR | 14 May 2015, 18:08 |
| Q4 2014 | 62 | $126,410,000 | +$25,052,748 | -$9,376,642 | +$15,676,106 | PCYC, ATRC, ASPX, NXTM, DSCO | 13F-HR | 13 Feb 2015, 18:30 |
| Q3 2014 | 59 | $99,148,000 | +$19,047,916 | -$12,205,201 | +$6,842,715 | PCYC, DSCO, ATRC, NXTM, PODD | 13F-HR | 13 Nov 2014, 18:24 |
| Q2 2014 | 49 | $105,516,000 | +$11,188,836 | -$12,685,246 | -$1,496,410 | AMPE, ATRC, PCYC, DSCO, NXTM | 13F-HR | 14 Aug 2014, 17:24 |
| Q1 2014 | 46 | $116,350,000 | +$24,776,389 | -$16,270,743 | +$8,505,646 | DSCO, PCYC, ATRC, AMPE, NVDQ | 13F-HR | 14 May 2014, 18:38 |
| Q4 2013 | 47 | $97,156,000 | $0 | $0 | $0 | DSCO, PCYC, ATRC, STXS, GIVN | 13F-HR | 13 Feb 2014, 19:08 |