| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 14% | +30% | $277,876,336 | +$109,228,632 | 7,652,255 | +65% | FMR LLC | 31 Dec 2025 |
| SR ONE CAPITAL MANAGEMENT, LLC | 9.4% | $111,851,442 | 5,037,854 | SR One Capital Management, LLC | 09 Oct 2025 | |||
| InnoCare Pharma Inc. | 9.4% | $111,026,500 | 5,000,000 | InnoCare Pharma Inc. | 07 Oct 2025 | |||
| Enavate Sciences GP, LLC | 7.3% | $87,013,952 | 3,919,159 | Enavate Sciences GP, LLC | 09 Oct 2025 | |||
| MOULDER LEON O JR | 5.2% | +7.2% | $101,943,527 | +$7,704,625 | 2,806,792 | +8.2% | Leon O. Moulder, Jr. | 07 Jan 2026 |
| Longitude Capital Partners IV, LLC | 4.9% | $58,425,578 | 2,631,522 | Patrick G. Enright | 09 Oct 2025 | |||
| Novo Holdings A/S | 4.7% | -12% | $44,400,000 | -$4,772,267 | 2,000,000 | -9.7% | Novo Holdings A/S | 30 Sep 2025 |
As of 30 Sep 2025, 78 institutional investors reported holding 34,774,383 shares of ZENAS BIOPHARMA INC - COMMON STOCK (ZBIO). This represents 65% of the company’s total 53,512,273 outstanding shares.
The largest institutional shareholders of ZENAS BIOPHARMA INC - COMMON STOCK (ZBIO) together control 64% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| SR One Capital Management, LP | 9.2% | 4,911,539 | 0% | 16% | $109,036,166 |
| FMR LLC | 9% | 4,820,370 | +45% | 0.01% | $107,012,214 |
| ENAVATE SCIENCES GP, LLC | 7% | 3,761,359 | 0% | 25% | $83,502,170 |
| NEA Management Company, LLC | 5.1% | 2,733,719 | 0% | 3.3% | $60,688,562 |
| NOVO HOLDINGS A/S | 3.7% | 2,000,000 | -11% | 2.9% | $44,400,000 |
| Fairmount Funds Management LLC | 3.5% | 1,892,806 | 0% | 3.8% | $42,020,293 |
| FEDERATED HERMES, INC. | 3.5% | 1,861,838 | 0% | 0.07% | $41,332,804 |
| NVP ASSOCIATES, LLC | 3.4% | 1,838,482 | 0% | 25% | $40,814,300 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2.9% | 1,562,942 | 0% | 0.53% | $34,697,312 |
| BlackRock, Inc. | 2.3% | 1,228,641 | +12% | 0% | $27,275,830 |
| Vivo Capital, LLC | 2.2% | 1,183,260 | 0% | 2.1% | $26,268,372 |
| VANGUARD GROUP INC | 2.2% | 1,162,758 | +17% | 0% | $25,813,227 |
| WELLINGTON MANAGEMENT GROUP LLP | 1.6% | 857,524 | -2.4% | 0% | $19,037,032 |
| ArrowMark Colorado Holdings LLC | 1.5% | 824,668 | -25% | 0.34% | $18,307,630 |
| Pivotal bioVenture Partners Investment Advisor LLC | 1.5% | 779,045 | 0% | 10% | $17,294,799 |
| Rock Springs Capital Management LP | 1.1% | 580,677 | -9.3% | 0.75% | $12,891,029 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.88% | 470,035 | +26% | 0% | $10,437,533 |
| STATE STREET CORP | 0.71% | 377,485 | +22% | 0% | $8,380,167 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0.7% | 374,298 | -23% | 0% | $8,310,000 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.33% | 178,396 | +46% | 0% | $3,960,391 |
| Eversept Partners, LP | 0.3% | 158,742 | -51% | 0.27% | $3,524,072 |
| SECTORAL ASSET MANAGEMENT INC | 0.28% | 152,025 | -28% | 2.1% | $3,374,955 |
| Invesco Ltd. | 0.27% | 145,796 | 0% | $3,236,671 | |
| NORTHERN TRUST CORP | 0.25% | 133,278 | +12% | 0% | $2,958,771 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0.21% | 112,612 | -27% | 0% | $2,316,429 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 1,571,094 | $57,046,620 | +$13,084,597 | $36.31 | 26 |
| 2025 Q3 | 34,774,383 | $771,813,059 | +$23,276,708 | $22.20 | 78 |
| 2025 Q2 | 34,055,191 | $329,977,952 | +$15,611,752 | $9.69 | 72 |
| 2025 Q1 | 32,489,801 | $256,715,238 | +$5,759,402 | $7.90 | 67 |
| 2024 Q4 | 31,699,756 | $259,632,936 | +$20,083,837 | $8.19 | 65 |
| 2024 Q3 | 24,771,152 | $418,526,187 | +$418,475,122 | $16.92 | 44 |