Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share (SPRO)

Q: What does CUSIP 84833T103 represent in this 13F holders report?

CUSIP 84833T103 is the security identifier for SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share used to aggregate holder disclosures.

Q: How many institutions held SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share in Q4 2021?

82 institutional investors reported SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share for Q4 2021. Use the holders table for investor-level position and value details.

CUSIP: 84833T103

Q4 2021 13F Holders as of 31 Dec 2021

Security type / class: Equity / Common Stock, par value $0.001 per share
Total 13F shares: 19,791,141
Total 13F value: $316,661,728
Share change: +125,417
Put/Call ratio: 108%
SEC-reported price per share: $16.01
Number of holders: 82
Value change: +$1,752,850
Number of buys: 26
Number of sells: 32
Shares outstanding: 55,705,828

Security key

84833T103

Report period

Q4 2021

Institutions

Top holders

SPRO full security history Ownership snapshot Full 13F holder table Newer quarter: Q1 2022 Previous quarter: Q3 2021 Spero Therapeutics, Inc. SEC filings Spero Therapeutics, Inc. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 84833T103

Newer quarter: Q1 2022 Previous quarter: Q3 2021

Recent filing periods:

Q2 2026 Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024

Ownership snapshot

Top reported holders of SPRO - Spero Therapeutics, Inc. - Common Stock, par value $0.001 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader

Aquilo Capital Management...

Disclosed value leader

Aquilo Capital Management...

Comparable rows

15/15

Latest evidence

30 Sep 2021

13F Lead comparable stake: 8.2% Showing 1-6 of 15 holder rows.

Quick read

Aquilo Capital Management, LLC leads the comparable SEC ownership view at 8.2%.

15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens Aquilo Capital Management, LLC's linked filing trail.

Comparable ownership Top 5

Aquilo Capital Management, LLC 8.2%

BVF INC/IL 3.2%

BlackRock Finance, Inc. 3.2%

Atlas Venture Associates IX, LLC 2.5%

VANGUARD GROUP INC 2.3%

Ownership % is shown only when SEC disclosures are safely comparable across share classes.

Detailed SEC evidence table Showing 1-6 of 15 holder rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
Aquilo Capital Management, LLC	13F Company 13F	8.2%	$84,017,000 4,563,688 shares	—	30 Sep 2021
BVF INC/IL	13F Company 13F	3.2%	$33,310,000 1,809,352 shares	—	30 Sep 2021
BlackRock Finance, Inc.	13F Company 13F	3.2%	$33,185,000 1,802,528 shares	—	30 Sep 2021
Atlas Venture Associates IX, LLC	13F Company 13F	2.5%	$25,350,000 1,376,968 shares	—	30 Sep 2021
VANGUARD GROUP INC	13F Company 13F	2.3%	$23,794,000 1,292,498 shares	—	30 Sep 2021
Rock Springs Capital Management LP	13F Company 13F	1.7%	$17,334,000 941,543 shares	—	30 Sep 2021

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q4 2021

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

19,791,141

Rows available

Investor	Option	Weight %	Change %	SEC-reported value	* Price	Shares	Share Change	Activity	Report Period

^* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q4 2021 vs Q3 2021 Across Filers

Q3 2021 holders

Q4 2021 holders

Holder diff

-5

Investor	Q3 2021 Shares	Q4 2021 Shares	Share Diff	Share Chg %	Q3 2021 value	Q4 2021 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend