Security key
413197104
CUSIP: 413197104
Security key
413197104
Report period
Q4 2021
Institutions
138
Top holders
10
Broader feeds
Reporting periods
Recent filing periods:
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC |
13F
|
Company |
8.5%
|
4,884,341
|
$187,217,000 | — | 30 Sep 2021 | |
| FMR LLC |
13F
|
Company |
7.2%
|
4,128,951
|
$158,263,000 | — | 30 Sep 2021 | |
| VANGUARD GROUP INC |
13F
|
Company |
5.4%
|
3,099,941
|
$118,820,000 | — | 30 Sep 2021 | |
| venBio Partners LLC |
13F
|
Company |
5.3%
|
3,063,194
|
$117,412,000 | — | 30 Sep 2021 | |
| Newlight Partners LP |
13F
|
Company |
3.3%
|
1,900,824
|
$72,859,000 | — | 30 Sep 2021 | |
| BlackRock Finance, Inc. |
13F
|
Company |
2.8%
|
1,614,173
|
$61,873,000 | — | 30 Sep 2021 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
13F
|
Company |
2.2%
|
1,240,415
|
$47,545,000 | — | 30 Sep 2021 | |
| JANUS HENDERSON GROUP PLC |
13F
|
Company |
2.1%
|
1,219,559
|
$46,746,000 | — | 30 Sep 2021 | |
| Blackstone Inc. |
13F
|
Company |
1.8%
|
1,048,951
|
$40,206,000 | — | 30 Sep 2021 | |
| Nan Fung Group Holdings Ltd |
13F
|
Company |
1.3%
|
768,708
|
$29,465,000 | — | 30 Sep 2021 | |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
13F
|
Company |
1.2%
|
667,784
|
$25,596,000 | — | 30 Sep 2021 | |
| ASHFORD CAPITAL MANAGEMENT INC |
13F
|
Company |
1.1%
|
630,473
|
$24,166,000 | — | 30 Sep 2021 | |
| Aisling Capital Management LP |
13F
|
Company |
1%
|
592,815
|
$22,723,000 | — | 30 Sep 2021 | |
| PERCEPTIVE ADVISORS LLC |
13F
|
Company |
0.85%
|
491,332
|
$18,833,000 | — | 30 Sep 2021 | |
| Nuveen Asset Management, LLC |
13F
|
Company |
0.8%
|
461,266
|
$17,680,000 | — | 30 Sep 2021 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
0.71%
|
411,110
|
$15,757,000 | — | 30 Sep 2021 | |
| STATE STREET CORP |
13F
|
Company |
0.69%
|
396,858
|
$15,212,000 | — | 30 Sep 2021 | |
| ROTHSCHILD & CO ASSET MANAGEMENT US INC. |
13F
|
Company |
0.52%
|
300,019
|
$11,500,000 | — | 30 Sep 2021 | |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC |
13F
|
Company |
0.41%
|
236,000
|
$9,020,000 | — | 30 Sep 2021 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13F
|
Company |
0.4%
|
232,029
|
$8,894,000 | — | 30 Sep 2021 | |
| ROYCE & ASSOCIATES LP |
13F
|
Company |
0.4%
|
229,390
|
$8,793,000 | — | 30 Sep 2021 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.37%
|
212,308
|
$8,138,000 | — | 30 Sep 2021 | |
| Rhenman & Partners Asset Management AB |
13F
|
Company |
0.36%
|
204,876
|
$7,853,000 | — | 30 Sep 2021 | |
| AMERICAN CENTURY COMPANIES INC |
13F
|
Company |
0.33%
|
188,811
|
$7,237,000 | — | 30 Sep 2021 | |
| Atle Fund Management AB |
13F
|
Company |
0.32%
|
185,000
|
$7,091,000 | — | 30 Sep 2021 | |
| MPM BioImpact LLC |
13F
|
Company |
0.26%
|
151,650
|
$5,813,000 | — | 30 Sep 2021 | |
| RICE HALL JAMES & ASSOCIATES, LLC |
13F
|
Company |
0.24%
|
139,214
|
$5,336,000 | — | 30 Sep 2021 | |
| Bellevue Group AG |
13F
|
Company |
0.22%
|
129,289
|
$4,956,000 | — | 30 Sep 2021 | |
| BAKER BROS. ADVISORS LP |
13F
|
Company |
0.21%
|
123,600
|
$4,738,000 | — | 30 Sep 2021 | |
| ADVISORY RESEARCH INC |
13F
|
Company |
0.21%
|
119,050
|
$4,563,000 | — | 30 Sep 2021 | |
| COMERICA BANK |
13F
|
Company |
0.17%
|
96,340
|
$3,934,000 | — | 30 Sep 2021 | |
| BALYASNY ASSET MANAGEMENT L.P. |
13F
|
Company |
0.18%
|
102,292
|
$3,921,000 | — | 30 Sep 2021 | |
| LMR Partners LLP |
13F
|
Company |
0.17%
|
100,000
|
$3,833,000 | — | 30 Sep 2021 | |
| DEUTSCHE BANK AG\ |
13F
|
Company |
0.16%
|
91,376
|
$3,502,000 | — | 30 Sep 2021 | |
| ExodusPoint Capital Management, LP |
13F
|
Company |
0.15%
|
87,716
|
$3,362,000 | — | 30 Sep 2021 | |
| CAMBIAR INVESTORS LLC |
13F
|
Company |
0.14%
|
82,222
|
$3,152,000 | — | 30 Sep 2021 | |
| WELLS FARGO & COMPANY/MN |
13F
|
Company |
0.14%
|
82,144
|
$3,148,000 | — | 30 Sep 2021 | |
| Ghost Tree Capital, LLC |
13F
|
Company |
0.13%
|
75,000
|
$2,875,000 | — | 30 Sep 2021 | |
| Bank of New York Mellon Corp |
13F
|
Company |
0.12%
|
68,553
|
$2,628,000 | — | 30 Sep 2021 | |
| SEI INVESTMENTS CO |
13F
|
Company |
0.11%
|
63,718
|
$2,442,000 | — | 30 Sep 2021 | |
| CIBC Private Wealth Group LLC |
13F
|
Company |
0.1%
|
60,000
|
$2,300,000 | — | 30 Sep 2021 | |
| Cubist Systematic Strategies, LLC |
13F
|
Company |
0.09%
|
54,633
|
$2,094,000 | — | 30 Sep 2021 | |
| GOLDMAN SACHS GROUP INC |
13F
|
Company |
0.09%
|
54,516
|
$2,090,000 | — | 30 Sep 2021 | |
| Jump Financial, LLC |
13F
|
Company |
0.09%
|
54,430
|
$2,087,000 | — | 30 Sep 2021 | |
| MILLENNIUM MANAGEMENT LLC |
13F
|
Company |
0.09%
|
53,662
|
$2,057,000 | — | 30 Sep 2021 | |
| MORGAN STANLEY |
13F
|
Company |
0.08%
|
44,484
|
$1,706,000 | — | 30 Sep 2021 | |
| CITADEL ADVISORS LLC |
13F
|
Company |
0.07%
|
41,047
|
$1,574,000 | — | 30 Sep 2021 | |
| Novo Holdings A/S |
13F
|
Company |
0.07%
|
40,000
|
$1,533,000 | — | 30 Sep 2021 | |
| RENAISSANCE TECHNOLOGIES LLC |
13F
|
Company |
0.07%
|
39,400
|
$1,510,000 | — | 30 Sep 2021 | |
| Swiss National Bank |
13F
|
Company |
0.07%
|
37,600
|
$1,441,000 | — | 30 Sep 2021 |
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
| Investor | Q3 2021 Shares | Q4 2021 Shares | Share Diff | Share Chg % | Q3 2021 Value $ | Q4 2021 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).