13F reference period
Q2 2026
CUSIP: 00370M103
13F reference period
Q2 2026
Institutions Reporting
304
Shares (Excl. Options)
Price
$133.26
The headline uses the Q2 2026 reference period after its reporting deadline. Available reports may still be incomplete or amended. Newer periods in the history table contain incoming reports and may be incomplete.
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Latest holder context comes from 304 institutions filings for Q2 2026.
Security key
00370M103
13F reference period
Q2 2026
13F holders
304
13D/G owners
5
CIK / CUSIP context first
Broader feeds
Open recent reporting periods for CUSIP 00370M103:
13D/G owners
Large-stake holder rows connected to Schedule 13D/G evidence.
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| TCG Crossover GP I, LLC | 7% | -23% | $816,945,267 | -$150,089,557 | 6,007,834 | -16% | Chen Yu | 30 Jun 2026 |
| Invus Global Management, LLC | 6% | +20% | $656,206,709 | +$122,757,849 | 4,825,759 | +23% | Raymond Debbane | 30 Jun 2026 |
| Sofinnova Crossover I | 4.3% | -34% | $471,190,328 | -$261,676,160 | 3,535,843 | -36% | Sofinnova Crossover I SLP | 02 Jul 2026 |
| Deep Track Capital, LP | 4.8% | $28,885,195 | 3,480,144 | Deep Track Capital, LP | 30 Jun 2025 | |||
| Venrock Healthcare Capital Partners III, L.P. | 0.8% | $48,964,292 | 576,729 | Venrock Healthcare Capital Partners III, L.P. | 30 Sep 2025 |
13F concentration
Largest 13F positions for this security by reported shares and value.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 7% | 6,007,834 | -7.3% | 19% | $800,603,959 |
| Darwin Global Management, Ltd. | 4.2% | 3,621,583 | +4.4% | 9.3% | $348,215,205 |
| Helikon Investments Ltd | 3.2% | 2,787,131 | +175% | 11% | $371,413,077 |
| Vestal Point Capital, LP | 2.7% | 2,349,443 | +57% | 7.3% | $313,086,774 |
| Jupiter Topco LLC | 2.2% | 1,913,933 | 0% | 0.1% | $255,132,750 |
| UBS Group AG | 2.1% | 1,844,918 | -59% | 0.04% | $245,853,773 |
| ADAR1 Capital Management, LLC | 2.1% | 1,804,703 | +29% | 11% | $240,494,722 |
| Caligan Partners LP | 1.8% | 1,557,924 | +6.6% | 10% | $207,608,952 |
| CITADEL ADVISORS LLC | 1.7% | 1,438,352 | +164% | 0.11% | $191,674,788 |
| MORGAN STANLEY | 1.7% | 1,432,185 | -16% | 0.01% | $190,852,973 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1.5% | 1,309,825 | -0.99% | 0.57% | $174,547,280 |
| RA CAPITAL MANAGEMENT, L.P. | 1.3% | 1,132,557 | 1.3% | $150,924,546 | |
| NORGES BANK | 1.3% | 1,100,000 | 0.01% | $146,586,000 | |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1.2% | 1,053,896 | +176% | 0.12% | $140,442,181 |
| Logos Global Management LP | 1.2% | 1,024,000 | +52% | 5.9% | $136,458,240 |
| Octagon Capital Advisors LP | 1.2% | 993,000 | +47% | 12% | $132,327,180 |
| BANK OF AMERICA CORP /DE/ | 1.1% | 971,439 | +32% | 0.01% | $129,453,961 |
| Eversept Partners, LP | 1.1% | 913,880 | -2.2% | 6.6% | $121,783,649 |
| GOLDMAN SACHS GROUP INC | 0.92% | 792,712 | +127% | 0.01% | $105,636,801 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0.89% | 765,332 | -0.08% | 5.6% | $101,988,142 |
| Cormorant Asset Management, LP | 0.79% | 675,000 | -11% | 4.6% | $89,950,500 |
| Boxer Capital Management, LLC | 0.7% | 605,000 | +202% | 6.1% | $80,622,300 |
| Balyasny Asset Management L.P. | 0.7% | 603,840 | +183% | 0.15% | $80,467,718 |
| Siren, L.L.C. | 0.67% | 576,000 | 1.6% | $76,757,760 | |
| BlackRock, Inc. | 0.67% | 574,061 | +34% | 0% | $76,499,369 |
Quarter history
Holder count, reported shares/value, and median price by quarter.
| Period | 13F Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q3 | 4,312,867 | $425,902,604 | +$110,394,956 | $99.02 | 93 |
| 2026 Q2 | 54,969,072 | $7,184,731,137 | +$598,421,308 | $133.26 | 304 |
| 2026 Q1 | 50,037,731 | $5,531,098,968 | -$766,727,516 | $111.35 | 254 |
| 2025 Q4 | 56,312,422 | $7,607,004,075 | +$630,821,272 | $134.86 | 247 |
| 2025 Q3 | 51,964,814 | $4,408,157,076 | +$2,126,922,733 | $84.90 | 165 |
| 2025 Q2 | 30,664,346 | $234,581,803 | -$5,694,979 | $7.65 | 43 |
| 2025 Q1 | 31,761,546 | $198,509,815 | +$9,164,590 | $6.25 | 46 |
| 2024 Q4 | 29,861,029 | $218,582,712 | +$7,328,424 | $7.32 | 47 |
| 2024 Q3 | 27,383,884 | $312,847,988 | -$8,252,199 | $11.52 | 40 |
| 2024 Q2 | 28,098,910 | $371,643,391 | +$62,450,093 | $13.22 | 38 |
| 2024 Q1 | 23,372,028 | $334,151,423 | +$31,771,567 | $14.30 | 36 |
| 2023 Q4 | 21,265,859 | $227,821,381 | +$227,821,381 | $10.70 | 30 |